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    • Abstract: http://www.greenfacts.org/ Copyright © GreenFacts page 1/5Scientific Facts on Source document:ECB (2003)Phthalate Summary & Details:

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http://www.greenfacts.org/ Copyright © GreenFacts page 1/5
Scientific Facts on Source document:
ECB (2003)
Phthalate Summary & Details:
GreenFacts (2005)
Di-butyl phthalate
Introduction: What are phthalates?..........2
Context - Dibutyl Phthalate (DBP) is 1. What are the properties of dibutyl phthalate
used in a wide range of products for (DBP)?.................................................2
everyday use such as plastics, paints, 2. How is DBP used? .................................2
inks and cosmetics. 3. Can DBP affect the environment?.............2
4. How can humans be exposed to DBP?......3
Its widespread use has raised some 5. What health effects can DBP cause in
concerns on the safety of this compound. laboratory animals?...............................3
Is DBP posing a risk to health or the 6. Does DBP pose risks to human health?.....3
environment? 7. Is further research needed?....................4
8. Conclusion............................................4
This Digest is a faithful summary of the leading scientific consensus report
produced in 2003 by the European Chemicals Bureau (ECB):
"Summary Risk Assessment Report (RAR 003) on Dibutyl Phthalate (DBP), 2003"
The full Digest is available at: http://www.greenfacts.org/en/dbp-dibutyl-phthalate/
This PDF Document is the Level 1 of a GreenFacts Digest. GreenFacts Digests are published in several
languages as questions and answers, in a copyrighted user-friendly Three-Level Structure of increasing
detail:
• Each question is answered in Level 1 with a short summary.
• These answers are developed in more detail in Level 2.
• Level 3 consists of the Source document, the internationally recognised scientific consensus
report which is faithfully summarised in Level 2 and further in Level 1.
All GreenFacts Digests are available at: http://www.greenfacts.org/
http://www.greenfacts.org/ Copyright © GreenFacts page 2/5
0. Introduction: What are phthalates?
Phthalates are widely used as additives in a range of plastics and
other materials that are found in many consumer products. They
make plastics, such as PVC, soft and flexible. They are not chemically
bound to plastics, so they can be released from consumer products
into the environment. There is public concern about phthalates Consumption of main
because of their widespread use and occurrence in the environment phthalates
[see Annex 1, p. 5]
as well as their potential effects on human health.
There is a wide range of different phthalates, which each have specific properties, uses,
and health effects. In the European Union, five of the most widely used phthalates have
been reviewed by the European Chemicals Bureau (DEHP, DBP, DINP, DIDP, and BBP).
By 2004, EU Risk Assessment Reports had been published for three of these phthalates:
DIDP, DINP, and DBP; assessements which have been summarised by GreenFacts. Because
of the strong similarities between the first two phthalates, they are described together.
1. What are the properties of dibutyl phthalate (DBP)?
DBP is a phthalate with the same core structure as DIDP and DINP but with two shorter
side chains attached, each having four carbon atoms. It is an oily liquid that is soluble in
fat and to some extent in water.
2. How is DBP used?
DBP has been produced for more than 40 years. In 1998, around 26 000 tonnes were
produced annually in the European Union but (in contrast to DIDP and DINP) its production
is going down. Like DIDP and DINP, it is used mainly as a plasticiser in PVC that is used to
make, film, sheeting, coated products, flooring, roofing, wall coverings, hoses, tubing, wires,
cables, injection moulded shoe soles, car undercoating and sealants. Non-PVC uses are in
adhesives, sealants, paints, printing inks, lubricants, nail polish, and perfumes, as a
suspension agent for solids in aerosols and in preventing foaming.
3. Can DBP affect the environment?
3.1 DBP as free chemical does not break down in water but does break down in soil.
3.2 DBP can be released at different stages: production, distribution, processing, use,
incineration and disposal.
3.3 High DBP concentrations in the environment are mostly found near by production and
processing sites in waste water and nearby surface water. DBP is also found in sediment
and soil, and in aquatic and soil-dwelling organisms near to sources. The highest levels in
air occur around PVC processing plants.
3.4 When DBP is present, it does not appear to have adverse effects on most organisms
in the environment. It is not toxic to microbes, plants or animals living in water, or to
earthworms and flies. On land, plants can be adversely affected by DBP present in the
atmosphere.
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3.5 The European Union Risk Assessment Report (the source of the present summary)
concluded that predicted concentrations in air around DBP production facilities could affect
plant life and that further risk reduction measures need to be taken.
4. How can humans be exposed to DBP?
Exposure of humans may occur from DBP present in the environment, workplace or consumer
products.
4.1 The highest exposures can occur in workplaces where DBP or DBP-containing products
are produced or used. Workers are mainly exposed through the air they breathe or through
skin contact.
4.2 Exposure of the general public is much lower and can occur through consumer products
and food packaging containing DBP. Exposure of children can occur through plastic toys
and baby equipment.
4.3 For the general public, the total daily intake through air, drinking water and food is
estimated to be low including around local production and use sites. DBP has been identified
in breast milk at relatively low concentrations.
5. What health effects can DBP cause in laboratory animals?
DBP is well absorbed by the body following ingestion or contact with the skin. The extent
of absorption when DBP is breathed in is not known but it is likely to be well absorbed. In
laboratory animals (as for DIDP and DINP) DBP mainly affects the liver but humans are
thought to be much less sensitive to these liver effects. DBP also reduces the number and
birth weight of rat offspring. Studies on developing rats show that DBP adversely affects
development of the reproductive system in males. It also affects the nasal cavity in rats
when DBP is breathed in.
6. Does DBP pose risks to human health?
Human exposures are compared with the lowest amounts needed to cause effects in
laboratory animals to determine the margin of safety.
6.1 Workers are considered to be at risk in some situations including repeated breathing
in of DBP during the production or use of products containing DBP and repeated skin exposure
during the use of products containing DBP in situations where DBP is formed as an aerosol.
It is concluded that in these situations there is a need for risk reduction measures but it is
noted that adequate worker protection may already be in place in some industrial premises.
6.2 Exposure of the general public is lower than that of workers, and adults, newborns,
infants and children are not considered to be at risk. This conclusion applies not only to
general exposure via the environment and food but also to specific scenarios such as regular
use of nail polish or DBP-containing adhesives and infants exposed to PVC toys and baby
equipment.
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7. Is further research needed?
It is concluded that:
• there is no need for further information or testing on DBP, but
• adequate worker protection is needed in workplaces involved in DBP production
or use of products containing DBP, and
• releases of DBP into air by production sites should be reduced in order to protect
plants.
8. Conclusion
Phthalates have played an important role in the creation of plastics and other materials
that have many versatile uses in industry, in medicine and in consumer products.
In view of more recent research and raising concerns about possible environmental and
health effects, the risks of exposure to phthalates are being kept under close review by
national and international bodies.
The most recent EU reviews on DIDP, DINP and DBP conclude that:
• more research may be necessary on the environmental effects of DIDP and
DINP;
• DIDP in toys may pose a risk;
• in some workplaces, exposure to DBP should be reduced;
• release of DBP in to the air from some workplaces should be reduced.
Other phthalates are currently being assessed by the European Chemicals Bureau.
GreenFacts comment:
Other EU reviews are currently underway and the information will be posted on this website
as soon as it becomes available:
• DEHP (Di-Ethyl-Hexyl-Phthalate) the most commonly used phthalate
• the use of phthalates in food packaging materials
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Annex
Annex 1:
Approximation of the relative importance of the consumption of four of the
main phthalates in the European Union in the 1990s
Source: GreenFacts based on ECB Summary Risk Assessment Reports on DIDP [see http://ecb.jrc.it/DOCUMENTS/
Existing-Chemicals/RISK_ASSESSMENT/SUMMARY/didpsum041.pdf] (2003), DINP [see http://ecb.jrc.it/DOCUMENTS/
Existing-Chemicals/RISK_ASSESSMENT/SUMMARY/dinpsum046.pdf] (2003), and DBP [see http://ecb.jrc.it/DOCUMENTS/
Existing-Chemicals/RISK_ASSESSMENT/SUMMARY/dibutylphthalatesum003.pdf] (2003-2004) and on the corresponding full
assessment reports


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